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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG1 All Species: 17.27
Human Site: S539 Identified Species: 34.55
UniProt: P19174 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19174 NP_002651.2 1290 148532 S539 E E E P K E V S S S T E L H S
Chimpanzee Pan troglodytes XP_514650 1630 185027 S879 E E E P K E V S S S T E L H S
Rhesus Macaque Macaca mulatta XP_001087295 1291 148567 S539 E E E P K E V S S S T E L H S
Dog Lupus familis XP_542998 1249 143812 A517 W F H G K L G A G R D G R H I
Cat Felis silvestris
Mouse Mus musculus Q62077 1302 149650 S539 E E E P K E A S S S T E L H S
Rat Rattus norvegicus P10686 1290 148530 S539 E E E P K E A S G S T E L H S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q2VRL0 637 72514
Frog Xenopus laevis Q32NH8 758 87399 F85 L Q S I A E E F K P E L C F T
Zebra Danio Brachydanio rerio A5D6R3 784 89362 P111 R R M T D L V P E K N C F T V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13217 1095 124845 Q422 E N H C N R A Q Q Y K L A K Y
Honey Bee Apis mellifera XP_624101 1134 132613 I461 D D D E E T V I R R P T D V L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 F267 D R G Q S K Y F L V E N M P F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 99.5 93.2 N.A. 95.3 96.9 N.A. N.A. 21.4 21.7 21.8 N.A. 21.4 45.1 N.A. 35.1
Protein Similarity: 100 79 99.7 94.5 N.A. 96.7 98.2 N.A. N.A. 32.4 37.3 36.3 N.A. 40 62 N.A. 50
P-Site Identity: 100 100 100 13.3 N.A. 93.3 86.6 N.A. N.A. 0 6.6 6.6 N.A. 6.6 6.6 N.A. 0
P-Site Similarity: 100 100 100 20 N.A. 93.3 86.6 N.A. N.A. 0 20 6.6 N.A. 6.6 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 25 9 0 0 0 0 9 0 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 9 9 0 0 % C
% Asp: 17 9 9 0 9 0 0 0 0 0 9 0 9 0 0 % D
% Glu: 50 42 42 9 9 50 9 0 9 0 17 42 0 0 0 % E
% Phe: 0 9 0 0 0 0 0 17 0 0 0 0 9 9 9 % F
% Gly: 0 0 9 9 0 0 9 0 17 0 0 9 0 0 0 % G
% His: 0 0 17 0 0 0 0 0 0 0 0 0 0 50 0 % H
% Ile: 0 0 0 9 0 0 0 9 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 50 9 0 0 9 9 9 0 0 9 0 % K
% Leu: 9 0 0 0 0 17 0 0 9 0 0 17 42 0 9 % L
% Met: 0 0 9 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 9 0 0 9 0 0 0 0 0 9 9 0 0 0 % N
% Pro: 0 0 0 42 0 0 0 9 0 9 9 0 0 9 0 % P
% Gln: 0 9 0 9 0 0 0 9 9 0 0 0 0 0 0 % Q
% Arg: 9 17 0 0 0 9 0 0 9 17 0 0 9 0 0 % R
% Ser: 0 0 9 0 9 0 0 42 34 42 0 0 0 0 42 % S
% Thr: 0 0 0 9 0 9 0 0 0 0 42 9 0 9 9 % T
% Val: 0 0 0 0 0 0 42 0 0 9 0 0 0 9 9 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 0 0 9 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _